{"id":11921,"date":"2017-01-01T15:48:19","date_gmt":"2017-01-01T15:48:19","guid":{"rendered":"http:\/\/lequia-udg.com\/2017\/01\/01\/elimination-study-of-the-chemotherapy-drug-tamoxifen-by-different-advanced-oxidation-processes-transformation-products-and-toxicity-assessment\/"},"modified":"2024-04-18T17:19:49","modified_gmt":"2024-04-18T17:19:49","slug":"elimination-study-of-the-chemotherapy-drug-tamoxifen-by-different-advanced-oxidation-processes-transformation-products-and-toxicity-assessment","status":"publish","type":"post","link":"https:\/\/lequia-udg.com\/ca\/2017\/01\/01\/elimination-study-of-the-chemotherapy-drug-tamoxifen-by-different-advanced-oxidation-processes-transformation-products-and-toxicity-assessment\/","title":{"rendered":"Elimination study of the chemotherapy drug tamoxifen by different advanced oxidation processes: Transformation products and toxicity assessment"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"11921\" class=\"elementor elementor-11921 elementor-6240\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5756a342 ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5756a342\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-19dcce2e ts-bg-color-over-image\" data-id=\"19dcce2e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-330eb836 ts-align-left elementor-widget elementor-widget-ts_heading\" data-id=\"330eb836\" data-element_type=\"widget\" data-widget_type=\"ts_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<div class=\"ts-heading-subheading ts-reverse-heading-yes animation-style4\"><h4 class=\"ts-custom-heading ts-custom-subtitle\">\r\n\t\t\t\r\n\t\t\t\tAuthors: Laura Ferrando-Climent, Rafael Gonzalez-Olmos, Alba Anfruns, Ignasi Aymerich, Lluis Corominas, Dami\u00e0 Barcel\u00f3, Sara Rodriguez-Moza                                                                                                         \r\n\t\t\t\r\n\t\t\t<\/h4>\r\n\t\t<h2 class=\"ts-custom-heading ts-custom-heading-title\">\r\n\t\t\t\r\n\t\t\t\tElimination study of the chemotherapy drug tamoxifen by different advanced oxidation processes: Transformation products and toxicity assessment\r\n\t\t\t\r\n\t\t\t<\/h2>\r\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-27fe2661 ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27fe2661\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7cad0133 ts-bg-color-over-image\" data-id=\"7cad0133\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5199eb7a elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5199eb7a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Tamoxifen is a chemotherapy drug considered as recalcitrant contaminant (with low biodegradability in conventional activated sludge wastewater treatment), bioaccumulative, ubiquitous, and potentially hazardous for the environment. This work studies the removal of Tamoxifen from water by advanced oxidation processes, paying special attention to the formation of transformation products (TPs) and to the evolution of toxicity (using the Microtox<sup>\u00ae<\/sup> bioassay) during the oxidation processes. Five types of treatments were evaluated combining different technologies based on ozone, hydrogen peroxide and UV radiation: i) O<sub>3<\/sub>, ii) O<sub>3<\/sub>\/UV, iii) O<sub>3<\/sub>\/H<sub>2<\/sub>O<sub>2<\/sub> (peroxone), iv) UV and v) UV\/H<sub>2<\/sub>O<sub>2<\/sub>. Complete removal of tamoxifen was achieved after 30 min for all the treatments carried out with O<sub>3<\/sub> while a residual concentration (about 10% of initial one) was observed in the treatments based on UV and UV\/H<sub>2<\/sub>O<sub>2<\/sub> after 4 h of reaction. Eight TPs were tentatively identified and one (non-ionizable molecule) was suspected to be present by using ultra high performance liquid chromatography coupled to high resolution mass spectrometry. An increase of toxicity was observed during all the oxidation processes. In the case of ozone-based treatments that increase was attributed to the presence of some of the TPs identified, whereas in the case of UV-based treatments there was no clear correlation between toxicity and the identified TPs.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-30cb53ae ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"30cb53ae\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-71034f1d ts-bg-color-over-image\" data-id=\"71034f1d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-293fcbd0 elementor-widget elementor-widget-accordion\" data-id=\"293fcbd0\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6921\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-6921\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Informaci\u00f3 addicional<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6921\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-6921\"><table style=\"border: hidden;\">\n<tbody>\n<tr style=\"border-bottom: 1px solid #efefef;\">\n<td align=\"right\" width=\"200\"><strong>Any:<\/strong><\/td>\n<td>2017<\/td>\n<\/tr>\n<tr style=\"border-bottom: 1px solid #efefef;\">\n<td align=\"right\" width=\"200\"><strong>Autors:<\/strong><\/td>\n<td>Laura Ferrando-Climent, Rafael Gonzalez-Olmos, Alba Anfruns, Ignasi Aymerich, Lluis Corominas, Dami\u00e0 Barcel\u00f3, Sara Rodriguez-Moza<\/td>\n<\/tr>\n<tr style=\"border-bottom: 1px solid #efefef;\">\n<td align=\"right\" width=\"200\"><strong>Refer\u00e8ncia:<\/strong><\/td>\n<td>Chemosphere, Volume 168, February 2017, Pages 284-292<\/td>\n<\/tr>\n<tr style=\"border-bottom: 1px solid #efefef;\">\n<td align=\"right\" width=\"200\"><strong>Enlla\u00e7:<\/strong><\/td>\n<td><a href=\"http:\/\/dx.doi.org\/10.1016\/j.chemosphere.2016.10.057\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.1016\/j.chemosphere.2016.10.057<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50c0eae elementor-widget elementor-widget-spacer\" data-id=\"50c0eae\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Authors: Laura Ferrando-Climent, Rafael Gonzalez-Olmos, Alba Anfruns, Ignasi Aymerich, Lluis Corominas, Dami\u00e0 Barcel\u00f3, Sara Rodriguez-Moza Elimination study of the chemotherapy drug tamoxifen by different advanced oxidation processes: Transformation products and toxicity assessment Tamoxifen is a chemotherapy drug considered as recalcitrant contaminant (with low biodegradability in conventional activated sludge wastewater treatment), bioaccumulative, ubiquitous, and potentially hazardous &hellip; 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